For example, if they can not natively perceive dark matter or perceive magnetic fields (like magnetoception in birds), they may not be able to perceive it like animals process that naturally, even through bio-technological enhancement (or with a super bio-computer inside their head).
In my own view, I call them Musculars and doomed for this hybridization process may occur in the early stage of one intelligent species development : the shift taking the whole species away from natural biological evolution (Theory of Evolution — Darwin). All evolution steps becoming the results of complex calculus with cybernetic nurturing and no place for nature's magic...
Do you see the drift from there ? What will this species look like 1 000 or 10 000 years further in time ? What if Humankind take this shift now ? Or in 150 years ?
To widen the question : can processing time can surpass nature ?